About Me

I'm interested in understanding what happens in our brains when we make simple decisions—with a focus on understanding what specific parts of the brain compel us to move under different circumstances. I am currently an AP Giannini Fellow working in the Deisseroth laboratory at Stanford University. Previously I started a company, CTRL-labs, that uses ideas related to my doctoral work to build non-invasive technologies for decoding motor intention. I completed my PhD at Columbia University, back in 2015, working with Liam Paninski and Thomas Jessell.

A more complete publication list can be found on my Google Scholar profile.

Publications

• Marshel, J.H.*, Kim, Y.S.*, Machado, T.A.* , Quirin S.*, Benson, B., Kadmon, J., Raja, C., Chibukhchyan, A., Ramakrishnan, C., Inoue, M., Shane, J., McKnight, D., Yoshizawa, S., Kato, H., Ganguli, S., Deisseroth, K. "Cortical layer–specific critical dynamics triggering perception" Science 365 (6453), eaaw5202 (2019) * denotes co-first authorship.



Machado, T.A. , Pnevmatikakis, E., Paninski, L., Jessell, T.M., Miri, A. "Primacy of flexor locomotor pattern revealed by ancestral reversion of motor neuron identity" Cell 162: 338-350 (2015) Cover article.
• Berens, P. et al. "Community-based benchmarking improves spike inference from two-photon calcium imaging data" PLOS Computational Biology 14 (5), e10006157 (2018).
• Pnevmatikakis, E.A., Soudry, D., Gao, Y., Machado, T.A. , Merel, J., Pfau, D., Reardon, T., Mu, Y., Lacefield, C., Yang, W., Ahrens, M., Bruno, R., Jessell T.M., Peterka D.S., Yuste, R., Paninski, L. "Simultaneous denoising, deconvolution, and demixing of calcium imaging data" Neuron 89 (2): 285–299 (2016).
• Rad, K. R., Machado, T.A. , Jessell, T., Paninski, L. "Robust and scalable bayesian analysis of spatial neural data" Annals of Applied Statistics 11 (2): 598-637 (2017).
• Bikoff, J.B., Gabitto, M.I., Rivard, A.F., Drobac, E., Machado, T.A. , Miri, A., Brenner-Morton, S., Famojure, E., Diaz, C., Alvarez, F.J, Mentis, G.Z., Jessell, T. "Spinal Inhibitory Interneuron Diversity Delineates Variant Motor Microcircuits" Cell 165 (1): 207-219 (2016).
• Buesing, L., Machado, T.A. , Cunningham, J.P., Paninski, L. "Clustered factor analysis of multineuronal spike data" Advances in Neural Information Processing Systems: 3500-3508 (2014)
• Doi, E., Gauthier, J.L., Field, G.D., Shlens, J., Sher, A., Greschner, M., Machado, T.A. , Jepson, L.H., Mathieson, K., Gunning, D.E., Litke, A.M., Paninski, L., Chichilnisky, E.J., Simoncelli, E.P. "Efficient coding of spatial information in the primate retina" Journal of Neuroscience 32 (46): 16256-16264 (2012)
• Vogelstein, J.T., Packer, A.M., Machado, T.A. , Sippy, T., Babadi, B., Yuste, R., Paninski, L. "Fast non-negative deconvolution for spike train inference from population calcium imaging" Journal of Neurophysiology 104 (6): 3691-3704 (2010)
• Field, G.D., Gauthier, J.L., Sher, A., Greschner, M., Machado, T.A. , Jepson, L.H., Shlens, J., Gunning, D.E., Mathieson, K., Dabrowski, W., Paninski, L., Litke, A.M., Chichilnisky, E.J.. "Functional connectivity in the retina at the resolution of photoreceptors" Nature 467 (7316): 673- 677 (2010)